Isotretinoin for Acne. Isotretinoin side effects
Category: Health and Fitness » Acne
Acne - a disease of the sebaceous glands. Generally, acne is a painful red nodules. Acne located on the face, neck, chest and back. It is a chronic disease that causes severe emotional distress, especially among young people, and requires a long, thorough treatment.
Etiology of acne
Elements of acne are the result of clogging of sebaceous hair-ducts. This occurs when the accumulation of excess sebum and dead skin horny scales. Such conditions are favorable for the growth of bacteria that can lead to the appearance of the skin pustules.
In adolescence and early adulthood cause of acne can be a natural age-related changes of hormonal balance, as well as more serious hormonal changes associated with the violation of the production of sex hormones.
When horny scales accumulate in excess, they stick together and formed cork - comedo. This plug blocks the sebaceous duct-hair. As a result, sebum accumulates in the sebaceous gland. Under these conditions, bacteria that normally live in the sebaceous glands begin to proliferate. This leads to inflammation - the formation of pimples and pustules. In the pathogenesis of acne are set four interrelated factors: abnormal follicular hyperkeratosis, excess sebum formation, reproduction, Propionibacterium acnes (P. acnes) and inflammation. In addition, the nature and extent of secretion of the sebaceous glands affected by androgens, which may also play an important role in the pathogenesis of acne.
Treatment of acne
Acne treatment depends on the form of the disease. There are 3 forms of acne - mild, moderate and severe. For the treatment of each form of acne recommended special combination of drugs. Effective treatment of mild acne used local agents (drugs that are applied to the skin) - creams, gels and lotions. Rational treatment is based on a proper clinical evaluation. Should determine the duration of the current acne severity and location of the lesion.
One topical treatment may be indicated only for mild or moderate non-inflammatory acne, slight superficial inflammatory acne without scarring, as well as an adjunct to oral therapy in moderate or severe acne.
Treatment of Acne with Isotretinoin
Isotretinoin is a synthetic analogue of vitamin A. This drug is effective at all stages of the pathogenesis of acne. Isotretinoin side effects. It significantly reduces the production of sebum, reduces the formation of comedones by normalization of the level of differentiation of epithelial cells in the walls and mouth of the follicle. While taking isotretinoin reduced the number of P. acnes, which appears to be directly associated with a reduction of sebum secretion, since this organism uses sebum as a source of supply. The number of P. acnes remains depressed for a long time after discontinuation of therapy.
Treatment of Acne with Isotretinoin is the terminal differentiation of keratinocytes, normalizing redox and regenerative processes in which the keratinocytes (derivatives of vitamin A) play a key role. Isotretinoin, acting on the internal microflora, violates gene expression responsible for the synthesis of certain proteins, and is able to inhibit the production of the sebaceous glands and reduce their number. Due to this property are used most frequently found in dermatology for the treatment of acne. Isotretinoin interacts with nuclear receptors, affect the processes of cell differentiation of sebaceous glands, which leads to a marked decrease in their size, the suppression of the activity and a dramatic reduction in excretion of sebum. In this regard, Isotretinoin has quickly become the number one tool in the world for the treatment of acne.
Contraindications:
Isotretinoin - a drug with a strong teratogenic effect, so it is contraindicated in women who already are pregnant or could become pregnant during treatment. If pregnancy occurs during the period when a woman takes isotretinion, there is a very great danger of having a child with developmental disabilities.
During treatment and within 30 days after it is necessary to exclude blood samples from potential donors to fully exclude the possibility of getting pregnant patients this blood (a high risk of teratogenic and embryotoxic action). Women of childbearing age should use reliable contraception. The use of contraceptives should be advised even to those women who do not normally use contraception because of infertility.
Isotretinoin inhibits sebaceous glands and reduces sebum production, prevents the formation of comedones, reduces the growth of Propionibacterium acnes, reducing inflammation. isotretinion today is the only reliable treatment for severe acne, which gives stable high therapeutic effect with minimal side effects. Buy Isotretinoin - the most efficient and modern means of treating acne.
Etiology of acne
Elements of acne are the result of clogging of sebaceous hair-ducts. This occurs when the accumulation of excess sebum and dead skin horny scales. Such conditions are favorable for the growth of bacteria that can lead to the appearance of the skin pustules.
In adolescence and early adulthood cause of acne can be a natural age-related changes of hormonal balance, as well as more serious hormonal changes associated with the violation of the production of sex hormones.
When horny scales accumulate in excess, they stick together and formed cork - comedo. This plug blocks the sebaceous duct-hair. As a result, sebum accumulates in the sebaceous gland. Under these conditions, bacteria that normally live in the sebaceous glands begin to proliferate. This leads to inflammation - the formation of pimples and pustules. In the pathogenesis of acne are set four interrelated factors: abnormal follicular hyperkeratosis, excess sebum formation, reproduction, Propionibacterium acnes (P. acnes) and inflammation. In addition, the nature and extent of secretion of the sebaceous glands affected by androgens, which may also play an important role in the pathogenesis of acne.
Treatment of acne
Acne treatment depends on the form of the disease. There are 3 forms of acne - mild, moderate and severe. For the treatment of each form of acne recommended special combination of drugs. Effective treatment of mild acne used local agents (drugs that are applied to the skin) - creams, gels and lotions. Rational treatment is based on a proper clinical evaluation. Should determine the duration of the current acne severity and location of the lesion.
One topical treatment may be indicated only for mild or moderate non-inflammatory acne, slight superficial inflammatory acne without scarring, as well as an adjunct to oral therapy in moderate or severe acne.
Treatment of Acne with Isotretinoin
Isotretinoin is a synthetic analogue of vitamin A. This drug is effective at all stages of the pathogenesis of acne. Isotretinoin side effects. It significantly reduces the production of sebum, reduces the formation of comedones by normalization of the level of differentiation of epithelial cells in the walls and mouth of the follicle. While taking isotretinoin reduced the number of P. acnes, which appears to be directly associated with a reduction of sebum secretion, since this organism uses sebum as a source of supply. The number of P. acnes remains depressed for a long time after discontinuation of therapy.
Treatment of Acne with Isotretinoin is the terminal differentiation of keratinocytes, normalizing redox and regenerative processes in which the keratinocytes (derivatives of vitamin A) play a key role. Isotretinoin, acting on the internal microflora, violates gene expression responsible for the synthesis of certain proteins, and is able to inhibit the production of the sebaceous glands and reduce their number. Due to this property are used most frequently found in dermatology for the treatment of acne. Isotretinoin interacts with nuclear receptors, affect the processes of cell differentiation of sebaceous glands, which leads to a marked decrease in their size, the suppression of the activity and a dramatic reduction in excretion of sebum. In this regard, Isotretinoin has quickly become the number one tool in the world for the treatment of acne.
Contraindications:
Isotretinoin - a drug with a strong teratogenic effect, so it is contraindicated in women who already are pregnant or could become pregnant during treatment. If pregnancy occurs during the period when a woman takes isotretinion, there is a very great danger of having a child with developmental disabilities.
During treatment and within 30 days after it is necessary to exclude blood samples from potential donors to fully exclude the possibility of getting pregnant patients this blood (a high risk of teratogenic and embryotoxic action). Women of childbearing age should use reliable contraception. The use of contraceptives should be advised even to those women who do not normally use contraception because of infertility.
Isotretinoin inhibits sebaceous glands and reduces sebum production, prevents the formation of comedones, reduces the growth of Propionibacterium acnes, reducing inflammation. isotretinion today is the only reliable treatment for severe acne, which gives stable high therapeutic effect with minimal side effects. Buy Isotretinoin - the most efficient and modern means of treating acne.